Vol. 7 Issue 2 Part A

Background and objectives: RhD is the most important and complex blood group system after ABO bloodgroup system for transfusion purpose. Weak D refers to reduced expression of D antigen on red blood cells. Our study is designed to determine the frequency of weak D antigen among healthy donors and patients coming to our tertiary care hospital which is important while labelling the donor and patient; as the donor is labelled D positive, patient as D negative also to highlight its clinical implications related to risk of alloimmunization in blood recipients having RhD negative blood group. The probable cause for reduced antigen D expression could be missense mutations seen in alleles of all weak D type.