Background: Chronic Kidney Disease (CKD) commonly affects about 13% of the population, often stemming from various conditions including diabetes, hypertension, and nephrotoxic drugs. A major complication of CKD is Secondary Hyperparathyroidism (SHPT), which disrupts the regulation of Parathyroid hormone, calcium, phosphorus, and vitamin D, and can adversely impact erythropoietin synthesis and bone marrow function. This study aimed to evaluate the impact of SHPT on the development of cytopenia in CKD patients undergoing hemodialysis.
Methods: Conducted at the Baghdad Iraqi Center of Dialysis/Medical City Complex, it analyzed data from 100 patients, with ages ranging from 19 to 80 years. Measurements included urea, creatinine, PTH, vitamin D, ionized calcium, and complete blood counts.
Results: Indicated various correlations between PTH and other blood biomarkers. Notably, a moderate positive correlation existed between PTH and urea levels, as well as with platelet counts, although these were not statistically significant. Weak positive correlations were observed between PTH and parameters like age, hemoglobin, creatinine, and white blood cell counts. Conversely, PTH levels were weakly negatively correlated with estimated Glomerular Filtration Rate (eGFR) and ionized calcium.
Conclusion: The study concluded that while there is an observable association between SHPT and cytopenia in CKD patients on hemodialysis, this association lacks statistical significance. Additionally, the assessment of ionized calcium and PTH levels suggested a prevalence of hypocalcemia, a common issue in advanced CKD and end-stage renal disease cases.
